Orexin Hormone Can Halt Increase on Weight

Do not be fooled by the fact that there is someone who every day eat large portions, but not as fat as other people who eat the same portions. Maybe the person has enough hormones orexin more than anyone else.

In a new study has shown that orexin-deficient mice, will be overweight when fed with high-fat diet compared with mice not lacking orexin. Orexin hormone is a hormone produced in the brain.

Although still a new finding, the researchers suggest that, levels of the hormone orexin might fairly be one way to help a person lose weight.

The researchers compared normal mice with mice engineered to be deficient orexin. When the rats were given high-fat diet for 6 weeks, mice that lacked orexin increased body weight by 45 percent, while the normal mice increased only 15 percent.

Results showed that in mice that lacked orexin weight gain occurred even though the mice ate less than normal mice.

“Without the hormone orexin, rat permanently programmed to become obese. While the hormone orexin, brown fat (brown fat) is activated so the body can burn more calories,” says researcher Devanjan Sikder, an assistant professor at the Sanford-Burnham Research Institute, as reported by My Health News Daily, Wednesday (10/05/2011).

“The results of our study can answer that question, why are some people who are overweight or obese has the fact that they do not eat too much,” said Sikder in a report published in the journal Cell Metabolism.

In humans, the hormone orexin deficiency is often found in people with narcolepsia, namely excessive drowsiness during the day which sometimes trigger uncontrollable sleep attacks. In other words, people are often sleepy during the day are more prone fat despite eating less.

Do not be fooled by the fact that there is someone who every day eat large portions, but not as fat as other people who eat the same portions. Maybe the person has enough hormones orexin more than anyone else.

In a new study has shown that orexin-deficient mice, will be overweight when fed with high-fat diet compared with mice not lacking orexin. Orexin hormone is a hormone produced in the brain.

Although still a new finding, the researchers suggest that, levels of the hormone orexin might fairly be one way to help a person lose weight.

The researchers compared normal mice with mice engineered to be deficient orexin. When the rats were given high-fat diet for 6 weeks, mice that lacked orexin increased body weight by 45 percent, while the normal mice increased only 15 percent.

Results showed that in mice that lacked orexin weight gain occurred even though the mice ate less than normal mice.

“Without the hormone orexin, rat permanently programmed to become obese. While the hormone orexin, brown fat (brown fat) is activated so the body can burn more calories,” says researcher Devanjan Sikder, an assistant professor at the Sanford-Burnham Research Institute, as reported by My Health News Daily, Wednesday (10/05/2011).

“The results of our study can answer that question, why are some people who are overweight or obese has the fact that they do not eat too much,” said Sikder in a report published in the journal Cell Metabolism.

In humans, the hormone orexin deficiency is often found in people with narcolepsia, namely excessive drowsiness during the day which sometimes trigger uncontrollable sleep attacks. In other words, people are often sleepy during the day are more prone fat despite eating less.

 

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